Hi Easy,
I think the first thing is to find out if she enjoys what she's doing. Or not.
Does she like having sisters to be closely involved with, or is she expressing unhappiness about it?
Does she feel used by her children? Are they paying their way and contributing to the functioning of the household or are they being parasites? Does she sound like a martyr when she talks about them?
Is being close to them part of what gives her life meaning? Does she love having a family?
Has she expressed a desire to change, or a wish that she could have more personal freedom?
Are you interested in having a closer relationship with her and feel there's no room for you because of all the family?
If things are basically fine with her, can you make room for all the other people in her life?
I think the most important question is, does she want things to change? Has she herself shown a desire to make changes in her life and relationships?
Hopalong