Author Topic: Depression may stem from interaction of nature and nurture--new study  (Read 2184 times)

Dr. Richard Grossman

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Hi everyone,

Here's an interesting study highlighting the interaction of genes and the environment as a cause of depression.

http://www.medicalnewstoday.com/articles/94160.php

BTW, the drug Wellbutrin is thought to impact the dopaminergic system.

Best,

Richard

Leah

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #1 on: January 16, 2008, 04:52:40 PM »

Thank you, Dr Grossman,

for the website link, as I have just read under the articles 'depression'

-- A depressive disorder is not the same as a passing "blue mood".

which validates my voice, that feeling disappointed, sad, or 'blue' - down in the dumps

is NOT depression!!

Grateful.

Leah
Jun 2006 voiceless seeking

April 2008 - "The Gaslight Effect" How to Spot & Survive by Dr. Robin Stern - freedom of understanding!

The Truth About Abuse VIDEO

tayana

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #2 on: January 16, 2008, 04:59:30 PM »
Leah,

Depression is not just feeling sad or down.

Depression is when you don't have the strength to get up in the morning.

Have no desire to do anything.

Wish the world would forget about you.

Wanting to die.

Wanting people to hurt you because you deserve the pain.

Depression isn't feeling "Blue."  Depression is black, pure, blackest despair that lets no light in, even when the light should be streaming in.

It's debilitating. 

We all feel depressed at times, but when your life is severely affected, it's time get help.
http://tayana.blogspot.com

You gain strength, courage and confidence by every experience in which you
really stop to look fear in the face. You must do the thing you think you cannot
do.
-Elanor Roosevelt

Leah

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #3 on: January 16, 2008, 05:13:36 PM »

Tayana,

Yeah, that's my understanding also, and my reason for proclaiming the validation of what depression is NOT.

There is a woman near here, in real life, who is making so many peoples lives a total misery.

Slapping a label onto them, of depression, if they so much dare to openly voice that they feel down.

Regardless of anyones explanation --- she is having none of it.

Feeling disappointed, sad, or 'blue' - down in the dumps ~~~ is NOT depression!!

Will she listen to anyones explanation?  No!

Leah
Jun 2006 voiceless seeking

April 2008 - "The Gaslight Effect" How to Spot & Survive by Dr. Robin Stern - freedom of understanding!

The Truth About Abuse VIDEO

teartracks

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #4 on: January 16, 2008, 06:06:40 PM »


Edited:  Please see new Teartracks thread.
« Last Edit: January 17, 2008, 12:34:35 AM by teartracks »

sunblue

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #5 on: January 16, 2008, 07:24:34 PM »
OK, I think this is definitely a topic that I can confidently speak about.  I am clinicially depressed and have been depressed since I was a young child.  However, it was only about 10 years ago that I was officially diagnosed.  Coming from an N family with a self-absorbed Nmom, Nsis and co-dependent dad, no one in my family ever cared enough to notice my depression or get me help.

In the course of my efforts to get help, I have undergone therapy and tried more than a dozen drugs, including Wellbutrin.  I am currently on another drug (Emsam), a new type of drug that is taken as a patch.  None of the drugs have really helped.  At one point I was hospitalized as well.

This I know.  For many people who are really and truly clinically depressed, drugs and cognitive behavioral therapy can work.  For these individuals, depression goes in and out of their lives, never entirely disappearing but controllable through treament.  Mine does not fit in this category.  I fall in that 20 percent of depressives whose depression is resistant to treatment.

However, I will say there is a huge diffierence between situational depression and clinicial depression.  Clinicial depression is made worse by stressors in life, one's upbringing and family problems.  However, if you remove those other factors, it would still be there.  With situational depression, once you deal with the negative situation or stressor, you can heal from your depression.  Clinicial depression is something you deal with every day for the rest of your life in most cases.  Situational depression is not so all pervasive, although it is equally painful and life damaging as clinicial depression.

Needless to say, I think I've read just about every self-help book, psychological study and report on the subject.  There have been new drugs but drugs by themselves don't always work.  However, without question, growing up in an N family only exacerbates depression, as does a genetic predisposition to the disease.  That's why the level of depression people experience lies on a continuum.  The more of these stressors and other factors you have, the worse the depression is.  Lack of self-esteem and positive self-image are inherent symptoms of depressives.  Therefore, growing up in an N household where the focus is never on you only makes the depression worse.

All the doctors I've ever been to have told me the same thing....that it is almost impossible to define what percentage of your depression is caused by genetic factors and which are caused by your environment or life circumstances.  Most often than not, it's a combinaton of the two.  For me, that factor is extremely, extremely frustrating.  It's like the chicken and the egg scenario.  Which came first?  Did I become depressed because of my family upbringing, environment and other stressors?  Or, did I encounter these stressors and negative life experiences because I was depressed.  No one can give me that answer.

At any rate, I know this.  When someone is clinically depressed, it becomes very challenging jsut doing the simple things that others take for granted.  The physical and mental fatigue, sense of hopelessness and failure, sadness and pain is truly, truly overwhelming.  No one in my family has ever been willing to acknowledge this or understand this.  They believe it is a personality trait, a sign of weakness.  It is not.  But it is perceived as such.  The really hard thing is that when you are clinically depressed, as opposed to situationally depressed, there is never any relief.  It never goes away.

Anyway, I thought the linked article was very good.  I've always said if I can't find a treatment that would cure me of my depression, my second wish would be for a pill I could give my family and others around me to take so that they could truly understand my condition, how it feels, how it manifests itself, and how difficult it is to get through life.  Being suicidal at times, being so hopeless and sad you can't function, is not easy and we depressives would be so helped by a little bit of empathy and understanding. 

Just my little two cents speech. 

Leah

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #6 on: January 16, 2008, 07:49:47 PM »
Dear (((( Sunblue ))))

Sincerely, I am humbled and grateful to you for openly and insightfully sharing, for the purpose of awareness, understanding and empathy.

My hearts desire is to extend real empathy and understanding of what depression actually means to someone.

With gratitude,

Love, Leah



Jun 2006 voiceless seeking

April 2008 - "The Gaslight Effect" How to Spot & Survive by Dr. Robin Stern - freedom of understanding!

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Hermes

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #7 on: January 17, 2008, 09:07:06 AM »
Something is definitely wrong, that depression is so widespread.


MAJOR DEPRESSION is a huge problem and it is growing. By looking at the statistics we can clear up common misconceptions and make it easier to tackle major depression at its root.

Major depression is the No.1 psychological disorder in the western world.(1) It is growing in all age groups, in virtually every community, and the growth is seen most in the young, especially teens. At the rate of increase, it will be the 2nd most disabling condition in the world by 2020, behind heart disease.

First and foremost, clinical or major depression is growing at an incredible rate.

People of all ages, backgrounds, lifestyles, and nationalities suffer from major depression, with a few exceptions.
Up to 20% of people experience symptoms of depression.
10 times more people suffer from major depression now than in 1945 (2)
The average age of first onset of major depression is 25-29

There is 10 times more major depression in people born after 1945 than in those born before. This clearly shows that the root cause of most depression is not a chemical imbalance.

Human genes do not change that fast.
Yet, it is estimated 35 to 40 million Americans living today will suffer from major depression at some time during their lives, with about half of this amount suffering from recurring depression symptoms.

http://www.clinical-depression.co.uk/Depression_Information/facts.htm


emptied

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #8 on: January 17, 2008, 12:17:38 PM »
Thank you Doctor Grossman for sharing this article. This supports a couple of my own beliefs about depression. I totally agree that TRUE depression has a genetic basis, but this does not explain why each of the children in a given family does not suffer from the disorder. I think that a certain amount of stress and lack of effective coping mechanisms then sort of turn on those genes that allow a given individual to become depressed.
     While I am very thankful for antidepressants, as I feel that they have saved my life, in my own experiences with them I have found that the ones that focus on Seratonin do not seem to provide much help. I have always told doctors that I need help with Dopamine and Norephinepherine. I am a strong believer that the antidepressents that work for one person do not necessarily work for others. I think that we are all individuals. In my own experience, I have found that a combination of medications work best for me, as well as lifestyle changes and changes in my thinking patterns. I think that the genetic studies that are going on, provide much hope. I am hoping that my children and grandchildren will be able to have someone check out a genetic profile and know, based on that information, which medications will help them. This would prevent them having to go through endless trials and failures while their very lives are at stake. The other thing that I would mention about depression is the fact that I believe folks should seek help early. In part because of the trails that may be needed to find the right medication, but also because I am not sure that the depression itself does not alter the brain, thereby making it more prone to depression or prone to deepening the depressive state. I know that stressors that are ongoing can change the way that the brain works, but I also believe that the depression itself changes the brain. I have found as I have continued my struggle with depression that my memory has been severely affected.
     The last point that I wanted to make was that people tend to associate depression with how a person feels. Granted, you feel terrible, but depression is actually about your brain being depressed. Your ability to cognate, have a discussion, think your way through a problem, do school work, etc. It is all affected. If you have ever had a conversation with someone that is extremely depressed, you will notice the lapse between what you say and what their normal response time will be. It is almost as though you can see that lag that is taking place, as they try to process the information and form a response. The brain simply is depressed and not working well.
     Thank you very much for this haven that you have set up for us. It is greatly appreciated.

tayana

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #9 on: January 17, 2008, 12:32:38 PM »
Emptied, I take an SSRI, and it works well for me.  I do think I have more problems with anxiety than I do with depression though, so maybe that's why the SSRI works so well.  My anxiety tends to lead to depression.  My Pdoc told me finding the right drug could take some time.  I also agree that the earlier people seek treatment, the better. 

As far as I know all members of my family, including my son, suffer from mild to severe depression.  My brother and I have both had treatment.  My parents never have, and I do notice things now, especially now that they are older, that have changed about them.  My father, for instance, used to be very miticulous about how he does things, but now he starts things and just rushes through them.  He's never done that in the past.  I won't even talk about my mother.

Hermes, one reason depression might be so much more widespread now is that more people are seeking treatment.  I was stunned when I first went to the Pdoc and found the waiting room full.
http://tayana.blogspot.com

You gain strength, courage and confidence by every experience in which you
really stop to look fear in the face. You must do the thing you think you cannot
do.
-Elanor Roosevelt

emptied

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #10 on: January 17, 2008, 12:40:06 PM »
Tayana,
     I am glad that you are finding relief with the SSRI. I really can't comment for people in general on medications because I really believe that what works for one person may not work for another. I am always concerned when I see a new medication come out with a bunch of hype and people talking about how great it is, because it worries me that folks will try it, find it doesn't work and give up. It is so important to keep in touch with your doc about what is and isn't working. Most medications are started as low doses and may need to be increased or a different medication may need to be tried. I think that lack of hope is a huge factor in depression and I am always afraid people may make one attempt at medication and give up hope. (((HUGS))) Hope you continue to feel better.

Leah

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #11 on: January 17, 2008, 12:44:14 PM »
Emptied:

The last point that I wanted to make was that people tend to associate depression with how a person feels. Granted, you feel terrible, but depression is actually about your brain being depressed. Your ability to cognate, have a discussion, think your way through a problem, do school work, etc. It is all affected. If you have ever had a conversation with someone that is extremely depressed, you will notice the lapse between what you say and what their normal response time will be. It is almost as though you can see that lag that is taking place, as they try to process the information and form a response. The brain simply is depressed and not working well.
     Thank you very much for this haven that you have set up for us. It is greatly appreciated.



Dear E

Sincerely appreciate you sharing, especially, the above, which will help me understand, with genuine empathy, as is my hope.

Love to you,

Leah
Jun 2006 voiceless seeking

April 2008 - "The Gaslight Effect" How to Spot & Survive by Dr. Robin Stern - freedom of understanding!

The Truth About Abuse VIDEO

tayana

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Re: Depression may stem from interaction of nature and nurture--new study
« Reply #12 on: January 17, 2008, 04:26:22 PM »
Thanks Emptied.  I know what you are saying.  I also think it depends on the doctor.  My p-doc is really good.  She's adjusted my dosage twice and just gave me something for situational anxiety to take the edge off so I don't make myself sick. 

I think a lot of people expect drugs to be a cure all and that they are supposed to work immediately.  Unfortunately, that's not the case.  They aren't a cure all.  It took about two weeks before I saw real relief from my symptoms.  You've got to work with the doctor to see how they are working, or if the drug or dosage needs to be changed.

http://tayana.blogspot.com

You gain strength, courage and confidence by every experience in which you
really stop to look fear in the face. You must do the thing you think you cannot
do.
-Elanor Roosevelt